Hypoxia promotes airway differentiation in the human lung epithelium [Bulk RNA-seq]
RNA-seq (gene expression) · human · 18 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 18 samples: 6 × Normoxia_NTC vs 6 × Hypoxia_NTC vs 6 × Hypoxia_HIF1aGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Hypoxia promotes airway differentiation in the human lung epitheliumCell stem cell · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE272860_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1139139 and SRA study SRP521612. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 18 samples.
How we read this: 3 replicated groups read from 18 sample titles; they account for 18 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8413730 Normoxia_NTC_rep1 Normoxia_NTC
- GSM8413731 Normoxia_NTC_rep2 Normoxia_NTC
- GSM8413732 Normoxia_NTC_rep3 Normoxia_NTC
- GSM8413733 Normoxia_NTC_rep4 Normoxia_NTC
- GSM8413734 Normoxia_NTC_rep5 Normoxia_NTC
- GSM8413735 Normoxia_NTC_rep6 Normoxia_NTC
- GSM8413736 Hypoxia_NTC_rep1 Hypoxia_NTC
- GSM8413737 Hypoxia_NTC_rep2 Hypoxia_NTC
- GSM8413738 Hypoxia_NTC_rep3 Hypoxia_NTC
- GSM8413739 Hypoxia_NTC_rep4 Hypoxia_NTC
- GSM8413740 Hypoxia_NTC_rep5 Hypoxia_NTC
- GSM8413741 Hypoxia_NTC_rep6 Hypoxia_NTC
- GSM8413742 Hypoxia_HIF1a_rep1 Hypoxia_HIF1a
- GSM8413743 Hypoxia_HIF1a_rep2 Hypoxia_HIF1a
- GSM8413744 Hypoxia_HIF1a_rep3 Hypoxia_HIF1a
- GSM8413745 Hypoxia_HIF1a_rep4 Hypoxia_HIF1a
- GSM8413746 Hypoxia_HIF1a_rep5 Hypoxia_HIF1a
- GSM8413747 Hypoxia_HIF1a_rep6 Hypoxia_HIF1a
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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.