GEO series
Effect of overexpressing a dominant negative LXRalpha mutant in HepG2 cells
GSE273158
Homo sapiens
Expression profiling by high throughput sequencing
24 samples
2024/07/31
GPL24676
Summary
Dominant negative mutatons in nuclear receptors can repress target gene expression, thus having stronger effects than simple loss of gene function. We sought to characterise the effects of a dominant negative mutant (p.W443R) in the hepatoma cell line HepG2 using cell lines stably transfected with wild type and mutant LXR isoforms.
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Paper (PMID 39322746) ↗
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