← BioTransfer GEO Dataset Finder
GEO series

Transcriptomic characterization of human primary prostate stromal cells upon exposure to chemotherapy and treatment by a natural flavonoid apigenin

GSE273159 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2025/06/04 Platform GPL24676
Summary
Senescent cells accumulate in a wide variety of solid tissues of mammalian species with advancing age, functionally promoting chronic inflammation and causing age-related diseases. Apigenin is one of the most abundant flavonoids in fruits and vegetables of human diet with several demonstrated health benefits. The aim of the present study is to investigate the influence of apigenin, the natural phytochemical agent with antioxidant, anti-inflammatory and anticancer properties reported by former studies, on human primary stromal cells induced senescent in vitro by a genotoxic agent frequently used in clinical oncology. We mainly focused on the capacity of apigenin in controlling the expression of a full spectrum senescence-associated secretory phenotype (SASP), one of the major hallmarks of senescent cells.
Published in
Targeting Senescence with Apigenin Improves Chemotherapeutic Efficacy and Ameliorates Age-Related Conditions in Mice
Zhang H, Xu Q, Jiang Z et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 · PMID 40265973 · doi:10.1002/advs.202412950
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE273159_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 9 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1140262 and SRA study SRP522290. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 9 more — browse all 9 samples with per-sample file links →

Similar datasets

Search all human RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.