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scRNA-seq of human cerebral organoids derived from healthy and FOXG1 syndrome patients iPSCs at d105

GSE273180 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2025/05/21 Platform GPL24676
Summary
Disruptions in gene expression programs during nervous system development?affecting both transcriptional and post-transcriptional regulation?are implicated in a range of neurodevelopmental disorders. Among these, FOXG1 syndrome remains poorly understood, particularly with respect to the mechanistic role of its namesake gene, FOXG1. In this study, we performed single-cell RNA sequencing (scRNA-seq) on day 105 (d105) cerebral organoids derived from healthy controls as well as from iPSCs carrying FOXG1^del and FOXG1^c.460dupG mutations, to investigate cell type?specific gene expression changes.
Published in
The lincRNA Pantr1 is a FOXG1 target gene conferring site-specific chromatin binding of FOXG1
Gather F, Rauleac T, Akol I et al. · Nucleic acids research 2025 · PMID 40548942 · doi:10.1093/nar/gkaf539
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Also filed as BioProject PRJNA1140564 and SRA study SRP522417. Searching any of these in the dataset finder brings you back here.

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