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CD8+ TEMRA Memory T cells Associate with Asthma Symptom Duration and Escape Proliferation Arrest in Severe but Not Mild Asthma

GSE273201 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2025/03/24 Platform GPL30173
Summary
Aberrant immune response is a hallmark of asthma, with 5-10% of patients suffering from severe disease exhibiting poor response to standard treatment. A better understanding of the immune responses contributing to disease heterogeneity is critical for improving asthma management. Here we show a significant association of airway CD8+ effector memory T cells re-expressing CD45RA (TEMRAs), but not CD8+ CD45RO+ or tissue resident memory (TRM) T cells, with asthma duration in patients with severe asthma (SA) but not mild to moderate asthma (MMA). Higher frequencies of IFN-g+ CD8+ TEMRAs compared to IFN-g+ CD45RO+ T cells were detected in SA airways, and the TEMRAs from SA but not MMA patients proliferated ex vivo, although both expressed cellular senescence-associated biomarkers. Prompted by the transcriptomic profile of SA CD8+ TEMRAs and proliferative response to IL-15, airway IL15 expression measured higher in SA compared to MMA patients. Our findings add a new dimension to understanding asthma heterogeneity identifying IL-15 as a potential target for treatment.
Published in
CD8+ TEMRAs in severe asthma associate with asthma symptom duration and escape proliferation arrest
Ramonell RP, Oriss TB, McCreary-Partyka JC et al. · JCI insight 2025 · PMID 40048261 · doi:10.1172/jci.insight.185061
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Also filed as BioProject PRJNA1140598 and SRA study SRP522456. Searching any of these in the dataset finder brings you back here.

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