Engineered cytokine/antibody fusion proteins improve delivery of IL-2 to pro-inflammatory cells and promote antitumor activity
RNA-seq (gene expression) · human · 14 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 14 samples: 14 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Engineered cytokine/antibody fusion proteins improve IL-2 delivery to pro-inflammatory cells and promote antitumor activityJCI insight · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE273415_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1141569 and SRA study SRP522987. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 14 sample titles: 14 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8428011 RNA-seq human CD8+ T donor1 -Control
- GSM8428012 RNA-seq human CD8+ T donor1-IL2 -4h
- GSM8428013 RNA-seq human CD8+ T donor1-F10-4h
- GSM8428014 RNA-seq human CD8+ T donor1-4-4-20-4h
- GSM8428015 RNA-seq human CD8+ T donor1-IL2 -24h
- GSM8428016 RNA-seq human CD8+ T donor1-F10-24h
- GSM8428017 RNA-seq human CD8+ T donor1-4-4-20-24h
- GSM8428018 RNA-seq human CD8+ T donor2 -Control
- GSM8428019 RNA-seq human CD8+ T donor2-IL2 -4h
- GSM8428020 RNA-seq human CD8+ T donor2-F10-4h
- GSM8428021 RNA-seq human CD8+ T donor2-4-4-20-4h
- GSM8428022 RNA-seq human CD8+ T donor2-IL2 -24h
- GSM8428023 RNA-seq human CD8+ T donor2-F10-24h
- GSM8428024 RNA-seq human CD8+ T donor2-4-4-20-24h
- GSE241843 SARS-CoV-2 spike protein induces the cytokine release syndrome by stimulating T cells to produce more IL-2 12 samples shares il-2, cytokine
- GSE303680 PD1-targeted cis-delivery of an IL-2 variant induces a multifaceted anti-tumoral T cell response in human lung cancer 10 samples shares il-2, delivery
- GSE227098 IL-21 induces antitumor response in NK cells via CEBPD 60 samples shares il-2, antitumor
- GSE285814 SIRPa ablation overcomes exhaustion and enhances the antibody- and CAR-mediated antitumor activities of iPSC-derived CAR Macrophages 27 samples shares antitumor, antibody
- GSE287228 The pro-inflammatory cytokine IL6 suppresses mitochondrial function via the gp130-JAK1/STAT1/3-HIF1α/ERRα axis 15 samples shares pro-inflammatory, cytokine
- GSE216734 Gene expression profiles of chimeric cytokine receptor-engineered CAR-T cells 12 samples shares engineered, cytokine
- GSE302798 The pro-inflammatory cytokines IFN-α and TNF-α inhibit extravillous trophoblast invasion 9 samples shares pro-inflammatory, cytokine
- GSE271543 UCPVax, a CD4 helper peptide vaccine induces polyfunctional Th1 cells, antibody response and epitope spreading to improve antitumor immunity [scRNA-seq] 5 samples shares antitumor, antibody
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.