NKG2C and NKG2A coexpression defines a highly functional antiviral NK population in spontaneous HIV control
Single-cell RNA-seq · human · 3 samples
- What it is
- Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart. Read from the summary: GEO's own type field only says 'expression profiling by sequencing', so confirm it in the paper.
- Organism
- Homo sapiens (human)
- Samples
- 3 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- NKG2C and NKG2A coexpression defines a highly functional antiviral NK population in spontaneous HIV controlJCI insight · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE273423_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1141886 and SRA study SRP523043. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 3 more — browse all 3 samples with per-sample file links →
- GSE297327 Spatial regulation of CD8+ T cells at the HLA-E-NKG2A axis drives HIV persistence in Lymph Node B Cell Follicles 18 samples shares nkg2a, hiv
- GSE298837 Blocking PD-1 engagement rapidly upregulates innate antiviral and immune functions that associate with HIV reservoir decay [bulkRNA-seq] 49 samples shares hiv, antiviral
- GSE298838 Blocking PD-1 engagement rapidly upregulates innate antiviral and immune functions that associate with HIV reservoir decay [scRNA-seq] 38 samples shares hiv, antiviral
- GSE273967 Loss of CD4 T cell responses to prior vaccines associate with inflammation and altered transcriptional signatures in HIV infection 174 samples shares hiv
- GSE274848 Association of smoking with neurocognition, inflammatory and myeloid cell activation profiles in people with HIV on ART 165 samples shares hiv
- GSE287060 Biomarkers that prospectively predict HIV-1 infection in high risk adults 146 samples shares hiv
- GSE324265 Contribution of cytotoxic CD8 T cells, neutrophils and type 1 interferon signaling to hyperinflammatory pathology in HIV associated TB meningitis [RNA-Seq] 125 samples shares hiv
- GSE271442 CD16 and CD57 Expressing Gamma Delta T Cells in Acute HIV-1 Infection are Associated with the Development of Neutralization Breadth 82 samples shares hiv
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.