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Gene expression analysis in C28/I2 cells: Comparison of OENC, DPP4 Overexpression, and DPP4 Overexpression with 4,5-Dicaffeoylquinic Acid Treatment Using RNA-Seq

GSE273447 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2025/02/19 Platform GPL24676
Summary
To examine the effects of DPP4 overexpression and its modulation by 4,5-Dicaffeoylquinic acid on chondrocytes, we established C28/I2 cell lines with DPP4 overexpression (DPP4OE), control empty vector (OENC), and DPP4OE treated with 4,5-Dicaffeoylquinic acid. Gene expression profiling analysis was performed using RNA sequencing (RNA-seq) with biological replicates to investigate the global transcriptomic changes associated with these conditions.
Published in
Dipeptidyl Peptidase 4 (DPP4) Exacerbates Osteoarthritis Progression in an Enzyme-Independent Manner
Li X, Zhang Z, Jiang W et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 · PMID 39680708 · doi:10.1002/advs.202410525
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Also filed as BioProject PRJNA1141939 and SRA study SRP523097. Searching any of these in the dataset finder brings you back here.

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