HDAC6 Inhibition Disrupts HDAC6-P300 Interaction Reshaping the Cancer Chromatin Landscape (ChIP-Seq)
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 13 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 13 samples: 13 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- HDAC6 inhibition disrupts HDAC6-P300 interaction reshaping the cancer chromatin landscapeClinical epigenetics · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE273645_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1142561 and SRA study SRP523409. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 13 sample titles: 13 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8434467 B16-F10-W2, H3K27Ac, ChIP-seq
- GSM8434468 B16-F10-K2, H3K27Ac, ChIP-seq
- GSM8434470 B16-F10-W3, H3K27Ac, ChIP-seq
- GSM8434472 B16-F10-K3, H3K27Ac, ChIP-seq
- GSM8434474 B16-F10-W4, H3K27Ac, ChIP-seq
- GSM8434476 B16-F10-Input
- GSM8434478 Jurkat-J1, H3K27Ac, ChIP-seq
- GSM8434480 Jurkat-H1, H3K27Ac, ChIP-seq
- GSM8434482 Jurkat-J2, H3K27Ac, ChIP-seq
- GSM8434484 Jurkat-H2, H3K27Ac, ChIP-seq
- GSM8434487 Jurkat-J4, H3K27Ac, ChIP-seq
- GSM8434489 Jurkat-H4, H3K27Ac, ChIP-seq
- GSM8434491 Jurkat-Input
- GSE296241 Sustained MYB activity drives emergent enhancer activation and precise enhancer-promoter interactions [ChIP-seq] 16 samples shares interaction, chip-seq
- GSE307112 Mapping the Dialogue: Decoding Alveolar Stem-Niche Interactions [I] 886 samples shares interaction
- GSE293919 Longitudinal monitoring of cytoplasmic RBP-RNA interactions and transcriptome in living cells by engineered protein nanocages 424 samples shares interaction
- GSE278418 Co-profiling of in situ RNA-protein interactions and transcriptome in single cells and tissues 278 samples shares interaction
- GSE63782 Transcriptional plasticity promotes primary and acquired resistance to BET bromodomain inhibition 103 samples shares inhibition
- GSE218715 EZH2 gain-of-function mutations distort H3K27me3 landscapes and transform transcriptional responses to PRC2 inhibition [RNA-seq] 88 samples shares inhibition
- GSE41747 MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors, despite transcriptional feedback onto ERK. 83 samples shares inhibition
- GSE236831 Rapid CRISPR/Cas12a-based dual-crRNA library screening in high fidelity reveals novel genetic interactions during hepatocarcinogenesis 62 samples shares interaction
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.