GEO series
Downregulation of MLF1 safeguards cardiomyocytes against senescence-associated chromatin opening
GSE273659
Homo sapiens
Genome binding/occupancy profiling by high throughput sequencing
12 samples
2025/01/29
GPL24676
Summary
Previous studies found that MLF1 mRNA levels tended to decline in aging hearts. Functional studies found that knockdown of MLF1 ameliorated the drug-induced cellular senescence phenotype. Here, we apply CUT&Tag to explore the underlying molecular mechanisms.
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Paper (PMID 39657728) ↗
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