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Aurora B and INCENP co-overexpression severely disrupts mitosis and distinctly modifies the global transcriptional landscape [RNA-seq]

GSE273663 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2025/05/06 Platform GPL24676
Summary
Aurora B kinase, as part of the chromosomal passenger complex (CPC), controls key processes during the cell cycle such as DNA compaction, genome partitioning or cytokinesis. Nonetheless, increased Aurora B levels are a potential threat for the cells and have been linked to different tumor types. We have carried out an exhaustive characterization of the global consequences of the overexpression of Aurora B and INCENP, the scaffold of the CPC and an activator of Aurora B kinase activity, in non-transformed human cells. Our data demonstrate, not only that an individual increase in the levels of Aurora B or INCENP have a different impact on the cells, but more importantly that their simultaneous overexpression stabilizes both CPC components, exacerbates Aurora B activity, severely impairs mitotic progression and chromosome dynamics, and has a distinctive and more dramatic effect on the transcriptional landscape of the cells.
Published in
Aurora B and INCENP co-overexpression severely disrupts mitosis and distinctly modifies the global transcriptional landscape
Galindo-Moreno M, Muñoz-Barrera M, Marcozzi C et al. · iScience 2025 · PMID 40530423 · doi:10.1016/j.isci.2025.112731
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Also filed as BioProject PRJNA1142588 and SRA study SRP523403. Searching any of these in the dataset finder brings you back here.

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