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Impact of BCL2 inhibitor Venetoclax on LNCaP cells

GSE273738 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2025/05/15 Platform GPL16791
Summary
In analyzing transcriptomic data from a clinical trial of neoadjuvant-intensive Androgen Deprivation Therapy, we observed increased mRNA expression of the hallmark antiapoptotic gene BCL2 in the prostate tumors of treated patients versus those of untreated patients. We showed that BCL2 overexpressed LNCaP cells exhibited resistance to enzalutamide, indicating that BCL2-overexpression leads to castration resistance and cellular plasticity.We treted the LNCaP cells with Bcl2 inhibitor Venetoclax in under castration of in presence of Androgen for 24 hr and observed that androgen supressed Venetoclax function
Published in
BCL2 drives castration resistance in castration-sensitive prostate cancer by orchestrating reciprocal crosstalk between oncogenic pathways
Hirani R, Nandakumar S, Zaman N et al. · Cell reports 2025 · PMID 40448998 · doi:10.1016/j.celrep.2025.115779
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Also filed as BioProject PRJNA1142953 and SRA study SRP523675. Searching any of these in the dataset finder brings you back here.

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