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BATF is a major driver of NK cell epigenetic reprogramming and dysfunction in AML[CUT&RUN]

GSE273749 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 8 samples Submitted 2024/08/31 Platform GPL18573
Summary
We identified BATF as a core transcription factor and the main mediator of this NK cell dysfunction in AML. our findings reveal a previously unidentified mechanism of NK immune evasion in AML manifested by epigenetic rewiring and inactivation of NK cells by myeloid blasts.  This work highlights the importance of using healthy allogeneic NK cells as adoptive cell therapy to treat patients with myeloid malignancies combined with strategies aimed at preventing the dysfunction by targeting the TGF-b pathway or BATF
Published in
BATF is a major driver of NK cell epigenetic reprogramming and dysfunction in AML
Kumar B, Singh A, Basar R et al. · Science translational medicine 2024 · PMID 39259809 · doi:10.1126/scitranslmed.adp0004
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Also filed as BioProject PRJNA1143027 and SRA study SRP523738. Searching any of these in the dataset finder brings you back here.

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