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RNA-Seq analysis of the effect of regorafenib on melanoma cells

GSE273844 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/09/06 Platform GPL24676
Summary
Melanoma is a malignant tumor with a terrible prognosis. In this study, we showed regorafenib has the ability to limit the growth, invasion and metastasis of melanoma cells but to upregulate apoptosis-prompting markers (cleaved-PARP and Bax). Moreover, ERK/E2F3 signaling influences regorafenib's ability to suppress melanoma cell growth. Ultimately, regorafenib significantly inhibits tumor growth in a dose-dependent manner in vivo.
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Direct links to NCBI, no account and no request form: the whole study as GSE273844_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1143462 and SRA study SRP523908. Searching any of these in the dataset finder brings you back here.

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