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Raw sequence reads of the transcriptomics for rapamycin-treated HeLa cells

GSE273888 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/05/01 Platform GPL24676
Summary
Rapamycin, known for its ability to inhibit the mammalian target of rapamycin (mTOR) pathway, which is a key player in metabolism, autophagy, tumorigensis and other crucial processes. However, due to the highly complexed, transient and context-dependent nature, the molecular details on how mTOR impacts cellular processes as well as specific diseases remained largely elusive. Given that mTOR is significantly associated with lysosome both physically and functionally, we have performed a proteomic study via the CAT-Lyso method to profile lysosomal dynamics upon mTOR perturbation in HeLa cells. Here, we further present the transcriptomic profiling of HeLa cells treated with rapamycin, in order to generate a multi-omic picture for mining biological information.
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Direct links to NCBI, no account and no request form: the whole study as GSE273888_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1143552 and SRA study SRP523946. Searching any of these in the dataset finder brings you back here.

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