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Integrated analysis of the anoikis-related signature identifies RAC3 as a novel therapeutic target in hepatocellular carcinoma

GSE273947 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/03/26 Platform GPL20795
Summary
Introduction: Anoikis is a form of programmed cell death. Anoikis resistance in hepatocellular carcinoma (HCC) promotes cancer cells shedding from the primary tumor site, thus contributing to survival and distant metastasis. However, the prognostic significance of anoikis-related genes (ARGs) and the biological functions of crucial genes in HCC have not been reported. Objectives: This study aimed to construct a model for predicting the outcome of patients with HCC based on ARGs and to investigate the clinicopathological significance and function of Rac family small GTPase 3 (RAC3) in HCC.
Published in
Integrated Analysis of the Anoikis-Related Signature Identifies Rac Family Small GTPase 3 as a Novel Tumor-Promoter Gene in Hepatocellular Carcinoma
Wu D, Liu ZK, Sun Y et al. · MedComm 2025 · PMID 40123831 · doi:10.1002/mco2.70125
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Also filed as BioProject PRJNA1144139 and SRA study SRP524130. Searching any of these in the dataset finder brings you back here.

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