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Effect of miR-34a overexpression on the transcriptome of HEK293T cells

GSE274168 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/07/23 Platform GPL21697
Summary
MicroRNAs regulate gene expression post-transcriptionally through binding to target sites in mRNAs. Predictions of target site efficiency are limited by our understanding of the structure-function relationship of microRNA-target complexes. Here, we overexpressed miR-34a in HEK293T cells and performed RNA-sequencing in order to study how different structural features of predicted miRNA-target complexes correlate with changes in gene expression.
Published in
Sequence, structure, and affinity of miR-34a binding sites determine repression efficacy
Sweetapple L, Kosek DM, Banijamali E et al. · Nucleic acids research 2025 · PMID 40671527 · doi:10.1093/nar/gkaf633
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Also filed as BioProject PRJNA1145337 and SRA study SRP524721. Searching any of these in the dataset finder brings you back here.

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