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TGFb-induced transcriptome profile in cancer cell lines

GSE274287 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/09/12 Platform GPL16791
Summary
TGFb plays many roles during tumor progression. It inhibits epithelial cell proliferation in the early stage but promotes tumor invasion by inducing epithelial-to-mesenchymal transition (EMT) in the late stage. Coupled with the strong EMT effect, TGFb exerts an overwhelming influence on modifying the extracellular matrix (ECM), which is generally thought to favor the adhesion and migration of tumor cells [4]. However, the regulation and function of ECM deposited in the tumor microenvironment by TGFb signaling have not been elucidated. Here, we performed a transcriptomic analysis using the human prostate cancer PC3U cell line and the human A549 lung carcinoma cell line. The top-upregulated genes in PC3U cells and A549 cells upon TGFb stimulation were identified to analyze the main regulatory function elicited by TGFb signaling. The GO enrichment analysis showed that extracellular matrix organization and the positive regulation of cell migration were the top regulatory functions.
Published in
The TβRI promotes migration and metastasis through thrombospondin 1 and ITGAV in prostate cancer cells
Mu Y, Wallenius A, Zang G et al. · Oncogene 2024 · PMID 39304722 · doi:10.1038/s41388-024-03165-3
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Also filed as BioProject PRJNA1145878 and SRA study SRP524965. Searching any of these in the dataset finder brings you back here.

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