Manifold roles of CCR7 chemokine GPCR in human trophoblast differentiation
Single-cell RNA-seq · human · 28 samples
- What it is
- Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart. Read from the summary: GEO's own type field only says 'expression profiling by sequencing', so confirm it in the paper.
- Organism
- Homo sapiens (human)
- Samples
- 28 samples: 8 conditions, mostly with about 4 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Manifold roles of the chemokine G-protein-coupled receptor CCR7 in differentiation of human trophoblast into extravillous and syncytiotrophoblast lineagesDevelopment (Cambridge, England) · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE274397_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1146339 and SRA study SRP525339. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 28 samples.
How we read this: 8 replicated groups read from 28 sample titles; they account for 28 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8448479 H9 naïve hESC, WT, biol rep1 H9 naïve hESC, WT, biol
- GSM8448480 H9 naïve hESC, WT, biol rep2 H9 naïve hESC, WT, biol
- GSM8448481 H9 naïve hESC, CCR7 KO, biol rep1 H9 naïve hESC, CCR7 KO,…
- GSM8448482 H9 naïve hESC, CCR7 KO, biol rep2 H9 naïve hESC, CCR7 KO,…
- GSM8448483 H9 hTSC, WT, biol rep1 H9 hTSC, WT, biol
- GSM8448484 H9 hTSC, WT, biol rep2 H9 hTSC, WT, biol
- GSM8448485 H9 hTSC, WT, biol rep3 H9 hTSC, WT, biol
- GSM8448486 H9 hTSC, WT, biol rep4 H9 hTSC, WT, biol
- GSM8448487 H9 hTSC, CCR7 KO, biol rep1 H9 hTSC, CCR7 KO, biol
- GSM8448488 H9 hTSC, CCR7 KO, biol rep2 H9 hTSC, CCR7 KO, biol
- GSM8448489 H9 hTSC, CCR7 KO, biol rep3 H9 hTSC, CCR7 KO, biol
- GSM8448490 H9 hTSC, CCR7 KO, biol rep4 H9 hTSC, CCR7 KO, biol
- GSM8448491 H9 EVT, WT, biol rep1 H9 EVT, WT, biol
- GSM8448492 H9 EVT, WT, biol rep2 H9 EVT, WT, biol
- GSM8448493 H9 EVT, WT, biol rep3 H9 EVT, WT, biol
- GSM8448494 H9 EVT, WT, biol rep4 H9 EVT, WT, biol
- GSM8448495 H9 EVT, CCR7 KO, biol rep1 H9 EVT, CCR7 KO, biol
- GSM8448496 H9 EVT, CCR7 KO, biol rep2 H9 EVT, CCR7 KO, biol
- GSM8448497 H9 EVT, CCR7 KO, biol rep3 H9 EVT, CCR7 KO, biol
- GSM8448498 H9 EVT, CCR7 KO, biol rep4 H9 EVT, CCR7 KO, biol
- GSM8448499 H9 STB, WT, biol rep1 H9 STB, WT, biol
- GSM8448500 H9 STB, WT, biol rep2 H9 STB, WT, biol
- GSM8448501 H9 STB, WT, biol rep3 H9 STB, WT, biol
- GSM8448502 H9 STB, WT, biol rep4 H9 STB, WT, biol
- GSM8448503 H9 STB, CCR7 KO, biol rep1 H9 STB, CCR7 KO, biol
- GSM8448504 H9 STB, CCR7 KO, biol rep2 H9 STB, CCR7 KO, biol
- GSM8448505 H9 STB, CCR7 KO, biol rep3 H9 STB, CCR7 KO, biol
- GSM8448506 H9 STB, CCR7 KO, biol rep4 H9 STB, CCR7 KO, biol
- GSE310267 OR7A10 GPCR engineering boosts CAR-NK therapy against solid tumors 36 samples shares gpcr
- GSE267153 Systems modeling of oncogenic G-protein and oncogenic GPCR signaling reveals unexpected differences in downstream signaling pathway activation [FAKi_experiment] 27 samples shares gpcr
- GSE290019 Endocytosis sculpts distinct cAMP signal transduction by endogenously coexpressed GPCRs 18 samples shares gpcr
- GSE287912 The combination of IL-7Ra and CCR7 is a highly specific marker to identify and purify homeostatically matured cDC2s (DC2hm). 18 samples shares ccr7
- GSE276594 Hypoxia and loss of GCM1 expression prevents differentiation and contact inhibition in human trophoblast stem cells [RNA-Seq 2] 45 samples shares trophoblast
- GSE278375 PPARG-centric transcriptional re-wiring during differentiation of human trophoblast stem cells into extravillous trophoblasts [RNA-seq] 32 samples shares trophoblast
- GSE276595 Hypoxia and loss of GCM1 expression prevents differentiation and contact inhibition in human trophoblast stem cells [RNA-Seq I] 26 samples shares trophoblast
- GSE336960 Phenotypic CRISPR screening identifies ZBTB10 as a novel regulator of human trophoblast differentiation 22 samples shares trophoblast
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.