Serotonin 2A Receptor Attenuates Psoriatic Inflammation by Suppressing IL-23 Secretion in Monocyte-derived Langerhans cells
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 12 samples: 3 × Healthy PBS vs 3 × Healthy DOI vs 3 × Psoriasis Lesioned PBS vs 3 × Psoriasis Lesioned DOIGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Serotonin 2A receptor attenuates psoriatic inflammation by suppressing IL-23 secretion in monocyte-derived Langerhans cellsNature communications · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE274449_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1146441 and SRA study SRP525466. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 6 samples read as cases, 6 as controls.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8449379 Healthy PBS 1 Healthy PBS
- GSM8449380 Healthy DOI 1 Healthy DOI
- GSM8449381 Healthy PBS 2 Healthy PBS
- GSM8449382 Healthy DOI 2 Healthy DOI
- GSM8449383 Healthy PBS 3 Healthy PBS
- GSM8449384 Healthy DOI 3 Healthy DOI
- GSM8449385 Psoriasis Lesioned PBS 1 Psoriasis Lesioned PBS
- GSM8449386 Psoriasis Lesioned DOI 1 Psoriasis Lesioned DOI
- GSM8449387 Psoriasis Lesioned PBS 2 Psoriasis Lesioned PBS
- GSM8449388 Psoriasis Lesioned DOI 2 Psoriasis Lesioned DOI
- GSM8449389 Psoriasis Lesioned PBS 3 Psoriasis Lesioned PBS
- GSM8449390 Psoriasis Lesioned DOI 3 Psoriasis Lesioned DOI
- GSE266075 Differentiation of monocyte-derived Langerhans cells in the presence of anandamide affects the immunomodulatory action of the cells 16 samples shares monocyte-derived, langerhans
- GSE291916 Natriuretic Peptides Modulate Monocyte-Derived Langerhans Cell Differentiation and Promote a Migratory Phenotype 14 samples shares monocyte-derived, langerhans
- GSE269175 Serotonin attenuates tumor-necrosis-factor-alpha-induced intestinal inflammation by interacting with human mucosal tissue 14 samples shares attenuates, serotonin
- GSE212836 Comparative Molecular Analysis of IL-17A and IL-23 Pathway Inhibition in Moderate-to-Severe Psoriasis: 4-Week Results from IXORA-R 199 samples shares il-23
- GSE290870 Assessing T-Cell Profile Shifts via IL-23 Inhibition by Guselkumab on Psoriasis. 72 samples shares il-23
- GSE278330 Systemic IL-23 blockade downregulates IL-23 receptor-expressing Type 17 T-cell subsets and upregulates regulatory gene expression in myeloid cells in human psoriasis skin 63 samples shares il-23
- GSE270499 IL-23 tunes inflammatory functions of human MAIT cells 21 samples shares il-23
- GSE243173 Epithelial-derived IL-23 promotes oral mucosal immunopathology 17 samples shares il-23
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.