Crosstalk between cancer-associated fibroblasts and non-neuroendocrine tumor cells in small cell lung cancer involves in glycolysis and antigen-presenting features
RNA-seq (gene expression) · human · 15 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Small cell lung cancerThis series is part of our curated briefing on it.
- Samples
- 15 samples: 5 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Crosstalk between cancer-associated fibroblasts and non-neuroendocrine tumor cells in small cell lung cancer involves in glycolysis and antigen-presenting featuresMolecular medicine (Cambridge, Mass.) · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE274458_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1146455 and SRA study SRP526019. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 15 samples.
How we read this: 5 replicated groups read from 15 sample titles; they account for 15 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8449565 H196_Mo_1 H196_Mo
- GSM8449566 H196_Mo_2 H196_Mo
- GSM8449568 H196_Mo_3 H196_Mo
- GSM8449569 H196_Co_1 H196_Co
- GSM8449570 H196_Co_2 H196_Co
- GSM8449571 H196_Co_3 H196_Co
- GSM8449572 MRC5_Mo_1 MRC5_Mo
- GSM8449573 MRC5_Mo_2 MRC5_Mo
- GSM8449574 MRC5_Mo_3 MRC5_Mo
- GSM8449575 MRC5_CoH69_1 MRC5_CoH69
- GSM8449576 MRC5_CoH69_2 MRC5_CoH69
- GSM8449577 MRC5_CoH69_3 MRC5_CoH69
- GSM8449578 MRC5_CoH196_1 MRC5_CoH196
- GSM8449579 MRC5_CoH196_2 MRC5_CoH196
- GSM8449580 MRC5_CoH196_3 MRC5_CoH196
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- GSE208446 Small cell lung cancer responds to inhibition of Jumonji enzyme in vitro and in vivo 90 samples same disease briefing
- GSE255095 An in vivo screening platform using PDX models reveals KEAP1, USP22 and other drivers of chemoresistance in small cell lung cancer 67 samples same disease briefing
- GSE281525 RNA-sequence data of clinically never-metastatic primary small cell lung cancer cases and small cell lung cancer metastasis cases, FOXA2 knock-down and overexpression in cell lines 61 samples same disease briefing
- GSE262597 EIF6 conditions drug-tolerant persister-like transdifferentiation in small cell lung carcinoma 56 samples same disease briefing
- GSE279100 Differential KEAP1/NRF2-mediated signaling widens the therapeutic window of redox-targeting drugs in SCLC therapy [seq] 50 samples same disease briefing
- GSE138474 Single-cell analyses reveal increasing intratumoral heterogeneity as an essential component of treatment resistance in small cell lung cancer 43 samples same disease briefing
- GSE273409 DNAPKCs as a therapeutic target in small cell lung cancer 36 samples same disease briefing
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.