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Single-cell resolution spatial analysis of antigen-presenting cancer-associated fibroblast niches [scRNA-seq]

GSE274609 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/09/15 Platform GPL24247
Summary
To understand the microenvironmental changes caused by Spp1 knockout, we digested the tumors from the control and knockout groups into single cell suspension and performed scRNA-seq. The scRNA-seq data suggested a significant increase of T cell infiltration into the stromal Spp1 knockout tumors.
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Direct links to NCBI, no account and no request form: the whole study as GSE274609_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1147284 and SRA study SRP525898. Searching any of these in the dataset finder brings you back here.

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