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Aging promotes reactivation of the Barr body at distal chromosome regions [ATAC]

GSE274694 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 8 samples Submitted 2025/03/21 Platform GPL24247
Summary
Decades ago, evidence of age-related reactivation of a single gene on the female inactive X chromosome was observed in mice. While stable silencing of the Barr body is crucial for balancing gene dosage between sexes, it remained unclear whether silencing is maintained during aging. Here, we employed allele-specific multi-omics approaches to capture a comprehensive catalog of genes escaping X chromosome inactivation throughout mouse development and aging. We found substantially elevated escape rates during aging across organs, occurring in multiple distinct cell types and concentrated at distal chromosome regions. Consistently, chromatin accessibility was increased across multiple megabases at chromosome ends, affecting regulatory elements of escapees. Since several age-specific escapees are linked to human diseases, their elevated expression in females might contribute to sex-biased disease progression observed during aging.
Published in
Aging promotes reactivation of the Barr body at distal chromosome regions
Hoelzl S, Hasenbein TP, Engelhardt S et al. · Nature aging 2025 · PMID 40312568 · doi:10.1038/s43587-025-00856-8
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Also filed as BioProject PRJNA1147677 and SRA study SRP526153. Searching any of these in the dataset finder brings you back here.

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