wild-type and MORC2 knock-out HEK293T cells
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 30 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 30 samples: 15 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- MORC2 is a phosphorylation-dependent DNA compaction machineNature communications · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE274916_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1148452 and SRA study SRP526163. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 6 samples read as cases, 14 as controls.
How we read this: 15 replicated groups read from 30 sample titles; they account for 30 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8457613 MORC2 KO HEK293T cell line - Replicate 1 MORC2 KO HEK293T cell l…
- GSM8457614 MORC2 KO HEK293T cell line - Replicate 2 MORC2 KO HEK293T cell l…
- GSM8457615 WT HEK293T cell line - Replicate 1 WT HEK293T cell line
- GSM8457616 WT HEK293T cell line - Replicate 2 WT HEK293T cell line
- GSM8457617 MORC2 KO HEK293T cell line, Replicate 1 MORC2 KO HEK293T cell l…
- GSM8457618 MORC2 KO HEK293T cell line, Replicate 2 MORC2 KO HEK293T cell l…
- GSM8457619 MORC2 WT HEK293T cell line, Replicate 1 MORC2 WT HEK293T cell l…
- GSM8457620 MORC2 WT HEK293T cell line, Replicate 2 MORC2 WT HEK293T cell l…
- GSM8461114 ChIP-seq H3K9me3 library from MORC2 KO HEK293T cell line - Replicate 1 ChIP-seq H3K9me3 librar…
- GSM8461115 ChIP-seq H3K9me3 library from MORC2 KO HEK293T cell line - Replicate 2 ChIP-seq H3K9me3 librar…
- GSM8461116 ChIP-seq H3K9me3 library from MORC2 WT HEK293T cell line - Replicate 1 ChIP-seq H3K9me3 librar…
- GSM8461117 ChIP-seq H3K9me3 library from MORC2 WT HEK293T cell line - Replicate 2 ChIP-seq H3K9me3 librar…
- GSM8461118 ChIP-seq IgG library from MORC2 KO HEK293T cell line - Replicate 1 ChIP-seq IgG library fr…
- GSM8461119 ChIP-seq IgG library from MORC2 KO HEK293T cell line - Replicate 2 ChIP-seq IgG library fr…
- GSM8461120 ChIP-seq IgG library from MORC2 WT HEK293T cell line - Replicate 1 ChIP-seq IgG library fr…
- GSM8461121 ChIP-seq IgG library from MORC2 WT HEK293T cell line - Replicate 2 ChIP-seq IgG library fr…
- GSM8461122 ChIP-seq MORC2 library from MORC2 KO HEK293T cell line - Replicate 1 ChIP-seq MORC2 library …
- GSM8461123 ChIP-seq MORC2 library from MORC2 KO HEK293T cell line - Replicate 2 ChIP-seq MORC2 library …
- GSM8461124 ChIP-seq MORC2 library from MORC2 WT HEK293T cell line - Replicate 1 ChIP-seq MORC2 library …
- GSM8461125 ChIP-seq MORC2 library from MORC2 WT HEK293T cell line - Replicate 2 ChIP-seq MORC2 library …
- GSM8661234 MORC2 KO HEK293T cell line with MORC2-GFP overexpression - Replicate 1 MORC2 KO HEK293T cell l…
- GSM8661235 MORC2 KO HEK293T cell line with MORC2-GFP overexpression - Replicate 2 MORC2 KO HEK293T cell l…
- GSM8661236 MORC2 KO HEK293T cell line with MORC2 phosphodead-GFP overexpression - Replicate 1 MORC2 KO HEK293T cell l…
- GSM8661237 MORC2 KO HEK293T cell line with MORC2 phosphodead-GFP overexpression - Replicate 2 MORC2 KO HEK293T cell l…
- GSM8661238 MORC2 KO HEK293T cell line with MORC2 phosphomimetic-GFP overexpression - Replicate 1 MORC2 KO HEK293T cell l…
- GSM8661239 MORC2 KO HEK293T cell line with MORC2 phosphomimetic-GFP overexpression - Replicate 2 MORC2 KO HEK293T cell l…
- GSM8661240 MORC2 WT HEK293T cell line with lipofectamine - Replicate 1 MORC2 WT HEK293T cell l…
- GSM8661241 MORC2 WT HEK293T cell line with lipofectamine - Replicate 2 MORC2 WT HEK293T cell l…
- GSM8661242 MORC2 WT HEK293T cell line with transfected MORC2- Replicate 1 MORC2 WT HEK293T cell l…
- GSM8661243 MORC2 WT HEK293T cell line with transfected MORC2 - Replicate 2 MORC2 WT HEK293T cell l…
- GSE274908 H3K9me3 and MORC2 ChIP-seq profiling of wild-type and MORC2-knock-out HEK293T cells 12 samples shares hek293t, morc2, wild-type, knock-out
- GSE274770 RNA-seq profiling of MORC2 knock-out HEK293T cells 4 samples shares hek293t, morc2, knock-out
- GSE242143 DNA methylation status determines the sensitivity of repeats to restriction by the HUSH-MORC2 complex 75 samples shares morc2
- GSE317890 Transcriptomic profiling of interferon responses induced by IVT sgRNAs in CRISPRi HEK293T cells 360 samples shares hek293t
- GSE315903 Temporal dynamics and functional annotation of transcriptome rhythmicity in HEK293T cells 39 samples shares hek293t
- GSE282179 SPT6 Regulates H3K14Ac Deposition in Mouse Embryonic Stem Cells [ChIP-seq-HEK293T] 24 samples shares hek293t
- GSE242550 SRSF1 knockdown in HEK293T cells with ionizing radiation 20 samples shares hek293t
- GSE247514 Transcriptional response induced by knockdown of HUWE1 in human HEK293T cells 20 samples shares hek293t
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.