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Next-generation sequencing is useful for quantitative analysis of the transcriptome of HMME-RGD@C3F8 NBs under low-frequency ultrasound irradiation combined with Elesclomol-Cu treated and untreated HCC cells

GSE274917 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2025/08/01 Platform GPL24676
Summary
Hepatocellular carcinoma has a hidden onset and is often found at an advanced stage clinically. Moreover, because it is insensitive to radiotherapy and chemotherapy, its treatment is often difficult. In this study, we constructed nanobubbles loaded with sonosensitizer HMME and tumor-targeting peptide RGD (HMME-RGD@C3F8 NBs) combined with cuproptosis inducer Elesclomol-Cu to achieve sonodynamic/cuproptosis combined therapy for hepatocellular carcinoma (HCC). Furthermore, to explore the mechanism of the enhanced anti-tumor efficacy of synergistic sonodynamic/cuproptosis therapy, RNA sequencing was performed.
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Direct links to NCBI, no account and no request form: the whole study as GSE274917_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1148468 and SRA study SRP526622. Searching any of these in the dataset finder brings you back here.

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