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Transcriptomic Landscape of Fibroblasts Under IL-1β Stimulation [ATAC-seq]

GSE274948 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 4 samples Submitted 2025/08/07 Platform GPL24676
Summary
In this study, we investigated the chromatin accessibility changes in human dermal fibroblasts in response to IL-1尾 stimulation, a key pro-inflammatory cytokine. Using ATAC-seq, we compared the open chromatin landscapes between control fibroblasts and those treated with IL-1尾. The data provide insights into the regulatory elements activated during fibroblast differentiation and their potential role in sustaining inflammation within the skin. These findings contribute to our understanding of fibroblast-mediated inflammation in autoimmune diseases like SLE and offer a resource for identifying novel therapeutic targets.
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Direct links to NCBI, no account and no request form: the whole study as GSE274948_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1148625 and SRA study SRP526673. Searching any of these in the dataset finder brings you back here.

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