GEO series
Role of GPNMB in Foam Cells Formation and Atherosclerosis Progression
GSE274954
Mus musculus
Expression profiling by high throughput sequencing
12 samples
2025/09/04
GPL24247
Summary
Currently, both reliable biomarkers for disease monitoring and specific therapeutic targets are needed to combat atherosclerosis, one of the dangerous lipid metabolism disorders. We observed attenuation of atherosclerosis in a GPNMB auto-mutant (GpnmbR150X) mouse model as well as in a myeloid-specific Gpnmb-knockout mouse model. Furthermore, in GpnmbR150X BMDMs, we observed that impaired lipid droplet formation, enhanced lipid oxidative metabolism, and more robust lipid degradation by the lysosomal pathway suppressed the macrophage foaming, thereby reducing the atherosclerotic burden of excess OxLDL.
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Paper (PMID 41238574) ↗
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