Soluble Mesothelin-Related Peptide as a Prognosticator in Pleural Mesothelioma Patients Receiving Checkpoint Immunotherapy
RNA-seq (gene expression) · human · 18 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- MesotheliomaThis series is part of our curated briefing on it.
- Samples
- 18 samples: 18 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Soluble mesothelin-related peptide as a prognosticator in pleural mesothelioma patients receiving checkpoint immunotherapyThe Journal of thoracic and cardiovascular surgery · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE274983_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1148672 and SRA study SRP526737. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 18 sample titles: 18 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8463502 MPM007_HIGH_SMRP
- GSM8463503 MPM030_HIGH_SMRP
- GSM8463504 MPM047_HIGH_SMRP
- GSM8463505 MPM054_HIGH_SMRP
- GSM8463506 MPM057_HIGH_SMRP
- GSM8463507 MPM073_HIGH_SMRP
- GSM8463508 MPM090_HIGH_SMRP
- GSM8463509 MPM179_HIGH_SMRP
- GSM8463510 MPM015_LOW_SMRP
- GSM8463511 MPM038_LOW_SMRP
- GSM8463512 MPM059_LOW_SMRP
- GSM8463513 MPM081_LOW_SMRP
- GSM8463514 MPM091_LOW_SMRP
- GSM8463515 MPM094_LOW_SMRP
- GSM8463516 MPM106_LOW_SMRP
- GSM8463517 MPM148_LOW_SMRP
- GSM8463518 MPM167_LOW_SMRP
- GSM8474541 MPM049_HIGH_SMRP
- GSE282239 A new soluble CSF1R-dimeric mutein with enhanced trapping of both CSF-1 and IL-34 reduces suppressive tumor-associated macrophages in mesothelioma. 12 samples same disease briefing · shares mesothelioma, soluble
- GSE252990 Coupling of response biomarkers between tumour and peripheral blood in patients undergoing chemoimmunotherapy 120 samples same disease briefing · shares immunotherapy
- GSE327167 Single-cell RNA-seq profiling of pleural mesothelioma and comparator pleural specimens 113 samples same disease briefing · shares mesothelioma
- GSE272176 PD-1 blockade mitigates surgery-induced immunosuppression and increases the efficacy of photodynamic therapy for malignant pleural mesothelioma 82 samples same disease briefing · shares mesothelioma
- GSE262853 Gene expression analysis in mesothelioma cell lines with and without K-975 treatment 36 samples same disease briefing · shares mesothelioma
- GSE250038 Gene expression data from precision cut tumor slices from head and neck or mesothelioma tumors 26 samples same disease briefing · shares mesothelioma
- GSE292620 Genome-wide CRISPR Screen Identifies BUB1 Kinase as a Druggable Vulnerability in Malignant Pleural Mesothelioma 12 samples same disease briefing · shares mesothelioma
- GSE326187 Combined dopamine receptor inhibition and radiotherapy target mesothelioma-initiating cells and increase survival in a mouse model of mesothelioma 12 samples same disease briefing · shares mesothelioma
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.