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An endothelial SOX18-mevalonate pathway axis enables repurposing of statins for infantile hemangioma [Day 4]

GSE275019 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/03/07 Platform GPL24676
Summary
Infantile hemangioma (IH) is the most common tumor in children and a paradigm for pathological vasculogenesis, angiogenesis and regression. Propranolol is the mainstay of treatment for IH. It inhibits hemangioma vessel formation via a β-adrenergic receptor independent effect of its R(+) enantiomer on the endothelial specific transcription factor sex-determining region Y (SRY) box transcription factor 18 (SOX18). Transcriptomic profiling of patient-derived hemangioma stem cells uncovered the mevalonate pathway (MVP) as a target of R(+) propranolol. Loss of SOX18 function confirmed R(+) propranolol mode of action on the MVP. Functional validation in preclinical IH models revealed that statins - targeting the MVP - are potent inhibitors of hemangioma vessel formation. We propose a novel SOX18-MVP-axis as a central regulator of IH pathogenesis and suggest statin repurposing to treat IH.
Published in
An endothelial SOX18-mevalonate pathway axis enables repurposing of statins for infantile hemangioma
Holm A, Graus MS, Wylie-Sears J et al. · The Journal of clinical investigation 2025 · PMID 39998898 · doi:10.1172/JCI179782
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Also filed as BioProject PRJNA1148977 and SRA study SRP526864. Searching any of these in the dataset finder brings you back here.

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