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Loss of an extensive ciliary connectome induces proteostasis and cell fate switching in a severe motile ciliopathy

GSE275070 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2025/03/24 Platform GPL24676
Summary
CCDC39 is a motile cilia protein associated with primary ciliary dyskinesia. We used single cell RNA sequencing (scRNA-seq) to analyze the changes in cells types and gene expression profile of subjects with variants in CCDC39 compared to healthy individuals
Published in
Undocking of an extensive ciliary network induces proteostasis and cell fate switching resulting in severe primary ciliary dyskinesia
Brody SL, Pan J, Huang T et al. · Science translational medicine 2025 · PMID 39879322 · doi:10.1126/scitranslmed.adp5173
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Also filed as BioProject PRJNA1149046 and SRA study SRP526928. Searching any of these in the dataset finder brings you back here.

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