CRAMP1-dependent histone H1 biogenesis is essential for topoisomerase II inhibitor tolerance [RNA-seq]
RNA-seq (gene expression) · human · 20 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 20 samples: 6 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- CRAMP1-dependent histone H1 biogenesis is essential for topoisomerase II inhibitor toleranceMolecular cell · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE275117_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1149476 and SRA study SRP527208. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 16 samples.
How we read this: 6 replicated groups read from 20 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8465835 WT cells, RNA, exp1, rep1 WT cells, RNA, exp1,
- GSM8465836 WT cells, RNA, exp1, rep2 WT cells, RNA, exp1,
- GSM8465837 WT cells, RNA, exp1, rep3 WT cells, RNA, exp1,
- GSM8465838 CRAMP1-KO cells, RNA, exp1, rep1 CRAMP1-KO cells, RNA, e…
- GSM8465839 CRAMP1-KO cells, RNA, exp1, rep2 CRAMP1-KO cells, RNA, e…
- GSM8465840 CRAMP1-KO cells, RNA, exp1, rep3 CRAMP1-KO cells, RNA, e…
- GSM8465841 WT cells, RNA, exp2, rep1 WT cells, RNA, exp2,
- GSM8465842 WT cells, RNA, exp2, rep2 WT cells, RNA, exp2,
- GSM8465843 WT cells, RNA, exp2, rep3 WT cells, RNA, exp2,
- GSM8465844 CRAMP1-KO cells, RNA, exp2, rep1 CRAMP1-KO cells, RNA, e…
- GSM8465845 CRAMP1-KO cells, RNA, exp2, rep2 CRAMP1-KO cells, RNA, e…
- GSM8465846 CRAMP1-KO cells, RNA, exp2, rep3 CRAMP1-KO cells, RNA, e…
- GSM8465847 CRAMP1-KO + GFP-CRAMP1 cells, RNA, exp2, rep1
- GSM8465848 CRAMP1-KO + GFP-CRAMP1 cells, RNA, exp2, rep2
- GSM8465849 CRAMP1-KO + GFP-CRAMP1-∆SANT cells, RNA, exp2, rep1 CRAMP1-KO + GFP-CRAMP1-…
- GSM8465850 CRAMP1-KO + GFP-CRAMP1-∆SANT cells, RNA, exp2, rep2
- GSM8465851 CRAMP1-KO + GFP-CRAMP1-∆SANT cells, RNA, exp2, rep3 CRAMP1-KO + GFP-CRAMP1-…
- GSM8465852 CRAMP1-KO + GFP-CRAMP1-∆GB-N cells, RNA, exp2, rep1 CRAMP1-KO + GFP-CRAMP1-…
- GSM8465853 CRAMP1-KO + GFP-CRAMP1-∆GB-N cells, RNA, exp2, rep2
- GSM8465854 CRAMP1-KO + GFP-CRAMP1-∆GB-N cells, RNA, exp2, rep3 CRAMP1-KO + GFP-CRAMP1-…
- GSE239381 Beta cell-specific PAK1 enrichment ameliorates diet-induced glucose intolerance by promoting insulin biogenesis and minimizing beta cell apoptosis [RNA-Seq] 20 samples shares biogenesis, tolerance, rna-seq
- GSE292860 Selective CDK7 Inhibition Sensitizes Tumors to Topoisomerase I Inhibitor-Antibody Drug Conjugates by Blocking The Transition of The RNA polymerase II Initiation Complex into Elongation [RNA-seq] 16 samples shares topoisomerase, inhibitor, rna-seq
- GSE298880 The kinase inhibitor GNF-7 is synthetically lethal in topoisomerase 1 deficient Ewing Sarcoma 29 samples shares topoisomerase, inhibitor
- GSE295919 The fetal specific gene LIN28B is essential for human fetal B-lymphopoiesis and initiation of KMT2A::AFF1 infant leukemia [RNA-seq] 27 samples shares essential, rna-seq
- GSE230263 The transcriptional co-repressor Runx1t1 is essential for N-Myc-driven neuroblastoma tumorigenesis [RNA-Seq 1] 26 samples shares essential, rna-seq
- GSE261691 7q11.23 CNV alters ribosomal biogenesis, mTOR and neuronal intrinsic excitability [RNA-seq] 24 samples shares biogenesis, rna-seq
- GSE262125 Paraspeckle-Independent Co-Transcriptional Regulation of Nuclear microRNA Biogenesis by SFPQ [RNA-seq] 24 samples shares biogenesis, rna-seq
- GSE297335 ABHD18 is essential for cardiolipin remodeling and its inhibition restores mitochondrial function in Barth Syndrome [RNA-Seq] 18 samples shares essential, rna-seq
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.