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Hematopoietic aging promotes cancer by fueling IL-1⍺-driven emergency myelopoiesis

GSE275150 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2024/10/23 Platform GPL19057
Summary
Age is a major risk factor for cancer, but how aging impacts tumor control remains unclear. Here, we establish that aging of the immune system, regardless of the age of the stroma and tumor, impacts lung cancer progression. Hematopoietic aging enhances emergency myelopoiesis, resulting in the local accumulation of myeloid progenitor-like cells in lung tumors. These cells are a major source of IL-1⍺ that drives the enhanced myeloid response. The age-associated decline of DNMT3A enhances IL-1⍺ production, and disrupting IL-1R1 signaling early during tumor development normalized myelopoiesis and slowed the growth of lung, colonic, and pancreatic tumors. In human tumors, we identified an enrichment for IL-1⍺-expressing monocyte-derived macrophages linked to age, poorer survival, and recurrence, unraveling how aging impacts cancer.
Published in
Hematopoietic aging promotes cancer by fueling IL-1⍺-driven emergency myelopoiesis
Park MD, Le Berichel J, Hamon P et al. · Science (New York, N.Y.) 2024 · PMID 39236155 · doi:10.1126/science.adn0327
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Also filed as BioProject PRJNA1149693 and SRA study SRP527306. Searching any of these in the dataset finder brings you back here.

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