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Repressive chromatin regions of Osimertinib-treated PC9 cells with H3K27me3 or H3K9me3 modifications through H3K27me3 ChIP-seq or H3K9me3 ChIP-seq

GSE275183 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 4 samples Submitted 2025/05/14 Platform GPL18573
Summary
Drug tolorent persister cells induced by target therapy are marked by elevated level of compressed chromatin structure. We use ChIP seq against H3K27me3 or H3K9me3 antibody to reveal the repressive chromatin regions of osimertinib-treated PC9 cells.
Published in
Epigenomic analysis identifies DTP subpopulation using HOPX to develop targeted therapy resistance in lung adenocarcinoma
Tian Y, Bhattacharya R, Yoo S et al. · iScience 2025 · PMID 40352726 · doi:10.1016/j.isci.2025.112387
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Also filed as BioProject PRJNA1149723. Searching any of these in the dataset finder brings you back here.

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