GEO series
Total RNA-seq analysis of WT and Gag chimera HIV-1 virions
GSE275260
Homo sapiens
Expression profiling by high throughput sequencing
62 samples
2025/10/15
GPL18573
Summary
To investigate how the major HIV-1 structural protein Gag packages viral genomes efficiently, we replaced the NC domain of Gag with RNA binding domains from heterologous cellular RNA binding proteins to generate Gag chimeras. We hypothesize that the Gag chimeras that preferentially bind to purine-rich RNA sequences will package viral genomes efficiently. We performed total RNA-seq to identify the RNAs that are packaged by WT Gag and Gag chimeras in HIV-1 virions.
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