← BioTransfer GEO Dataset Finder
GEO series

Effect of depletion of RNH1 on gene expression in KYSE510 cell

GSE275269 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/08/20 Platform GPL23227
Summary
Accumulation of R-loops causes DNA breaks and genome instability, as well as regulates tumorigenesis in a mechanism that remains poorly understood. We knockdown the ribonuclease RNase H1 (RNH1) to generate a cell model of induced R-loop accumulation. We showed that the expression of a large number of genes was disturbed after RNH1 knockdown, including 961 genes with more than twofold differences . The KEGG pathway indicates that the target genes are enriched in the Hippo signaling pathway, Wnt signaling pathway, and other tumor-associated biological processes .
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE275269_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1150151 and SRA study SRP527557. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 6 more — browse all 6 samples with per-sample file links →

Similar datasets

Search all human RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.