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Analysis of the chromatin accessibility in CPSF6-RARG or NUP98-RARG overexpressing hCD34+ cells compared to control hCD34+ cells using ATAC-seq.

GSE275304 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 6 samples Submitted 2024/10/16 Platform GPL34284
Summary
We found that RARG fusions selectively upregulated BCL2 and ATF3 in HSPCs, driving uncontrolled proliferation and disrupting the differentiation of RARG-AML cells.To investigate the mechanism how RARG fusions mediate activation of their downstream targets such as BCL2 and ATF3, we defined the chromatin accessibility using ATAC-seq assay in human CD34+ (hCD34+) cells with or without CPSF6::RARG or NUP98::RARG overexpression.
Published in
Oncogenic role of RARG rearrangements in acute myeloid leukemia resembling acute promyelocytic leukemia
Wang F, Zhao L, Tan Y et al. · Nature communications 2025 · PMID 39805831 · doi:10.1038/s41467-024-55047-7
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Also filed as BioProject PRJNA1150221 and SRA study SRP527602. Searching any of these in the dataset finder brings you back here.

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