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LINC00622 transcriptionally promotes RRAGD to repress mTORC1-modulated autophagic cell death by associating with BTF3 in cutaneous melanoma

GSE275315 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2025/02/19 Platform GPL21290
Summary
We report a novel long noncoding RNA, LINC00622, which modulates the mTORC1-regulated autophagy in cutaneous melanoma. Functionally, LINC00622 acts as an oncogene to promote the proliferation, colony formation, migration and invasion in melanoma while suppressing cell death. Mechanically, LINC00622 associates and recruits BTF3 to transcriptionally enhance RRAGD expression for activating mTORC1 and inhibiting autophagic cell death, which contributes to the development of cutaneous melanoma. Our findings not only demonstrated the oncogenic role of LINC00622 via RRAGD/mTORC1 axis to repress autophagic cell death in cutaneous melanoma, but also offer novel treatment targets for melanoma therapy.
Published in
LINC00622 transcriptionally promotes RRAGD to repress mTORC1-modulated autophagic cell death by associating with BTF3 in cutaneous melanoma
Li C, Wang K, Zhao L et al. · Cell death & disease 2025 · PMID 40651979 · doi:10.1038/s41419-025-07828-1
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Also filed as BioProject PRJNA1150244 and SRA study SRP534217. Searching any of these in the dataset finder brings you back here.

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