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MTHFD2-mediated ubiquitination and degradation of FOXO1 promote tongue squamous cell carcinoma progression

GSE275423 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/11/06 Platform GPL11154
Summary
In recent years, there has been an increasing focus on Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2), a key enzyme in one-carbon metabolism, and its expression levels and mechanisms in tumors. Research has shown that MTHFD2 is upregulated in various malignant tumors and is closely associated with tumor onset, progression, and prognosis. However, the role and mechanisms of MTHFD2 in Tongue Squamous Cell Carcinoma (TSCC) remain unclear. Our study found that MTHFD2 expression is significantly elevated in TSCC and is closely linked to poor prognosis. Furthermore, the knockdown of MTHFD2 notably impacts the proliferation and migration capabilities of TSCC cells. Therefore, MTHFD2 holds promise as a crucial therapeutic target for TSCC.
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Also filed as BioProject PRJNA1150640 and SRA study SRP527921. Searching any of these in the dataset finder brings you back here.

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