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Effect of PDCD11 silencing on gene expression in MDA-MB-231 cells

GSE275527 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/05/14 Platform GPL34284
Summary
We here reported that PDCD11 deletion results in G1/S arrest and inhibited proliferation and migration of MDA-MB-231 cells. To investigate how does PDCD11 regulate the malignant phenotype of cancer cells, we performed RNA-sea analysis and found that PDCD11 knockdown leads to reduced transcriptional levels of C-MYC target genes such as E2F1, MCM2, MCM4, MCM5, MCM6, MCM7, CCNE2, CCNA2, and SKP2. Taken together, our data indicate that PDCD11 facilitates G1/S transistion, proliferation, and migration of cancer cells by regulating C-MYC pathways.
Published in
PDCD11 Stabilizes C-MYC Oncoprotein by Hindering C-MYC-SKP2 Negative Feedback Loop to Facilitate Progression of p53-Mutant Breast and Colon Malignancies
Ding L, Ni W, Ma Y et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 · PMID 40051297 · doi:10.1002/advs.202502416
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Also filed as BioProject PRJNA1151625 and SRA study SRP528270. Searching any of these in the dataset finder brings you back here.

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