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White button mushroom intake modulates PMN-MDSCs, T, and NK cells’ function at the single cell level in prostate cancer patients (validation cohort)

GSE275574 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2024/10/16 Platform GPL24676
Summary
In prostate cancer patients following 3 months of white button mushroom consumption in freeze-dried tablet form, we observed the decline of circulating polymorphonuclear MDSCs (PMN-MDSCs), along with an increase of granzyme B positive CD8+ T cells and NK cells. Furthermore, single immune cell profiling of peripheral blood from WBM-treated patients revealed the transcriptional landscape of circulating immune cells. This methods showed a decrease in overall circulating PMN-MDSCs with suppression on the expression of STAT3/IRF1 and TGFβ signaling. Subclusters of PMN-MDSCs showed transcriptional profiles associated with "response to fungus", "neutrophil chemotaxis", "leukocyte aggregation", and "regulation of inflammatory response", which are associated with enhanced immune-modulated anti-tumor activity.
Published in
Reduction of myeloid-derived suppressor cells in prostate cancer murine models and patients following white button mushroom treatment
Wang X, Ma S, Twardowski P et al. · Clinical and translational medicine 2024 · PMID 39390760 · doi:10.1002/ctm2.70048
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Also filed as BioProject PRJNA1151694 and SRA study SRP528329. Searching any of these in the dataset finder brings you back here.

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