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Effect of cisplatin on gene expression of human umbilical vein endothelial cells

GSE275662 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/07/01 Platform GPL34284
Summary
Cisplatin (DDP) is a widely used chemotherapeutic agent that induces apoptosis in various cancer cells, but its effects on endothelial cells such as HUVEC (Human Umbilical Vein Endothelial Cells) are less well understood. This study aims to explore the transcriptional response of HUVEC cells to cisplatin treatment. RNA-seq analysis was performed to identify differentially expressed genes following cisplatin stimulation, providing insights into the molecular mechanisms underlying the cellular response to chemotherapy in endothelial cells. The results highlight key pathways and genes involved in the stress response, apoptosis, and cellular survival in HUVEC cells upon cisplatin treatment.
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Direct links to NCBI, no account and no request form: the whole study as GSE275662_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1152537 and SRA study SRP528658. Searching any of these in the dataset finder brings you back here.

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