Neddylation Status Determines the Therapeutic Sensitivity of BCR-ABL1-targeting Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Chronic myeloid leukemiaThis series is part of our curated briefing on it.
- Samples
- 12 samples: 3 × control K562 cells, vs 3 × MLN-treated K562 cells, vs 3 × IMA-treated K562 cells, vs 3 × MLN+IMA-treated K562 cells,Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Neddylation status determines the therapeutic sensitivity of tyrosine kinase inhibitors in chronic myeloid leukemiaScientific reports · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE275701_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1152590 and SRA study SRP528723. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 9 samples read as cases, 3 as controls.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8482990 control K562 cells, rep1 control K562 cells,
- GSM8482994 control K562 cells, rep2 control K562 cells,
- GSM8482996 control K562 cells, rep3 control K562 cells,
- GSM8482998 MLN-treated K562 cells, rep1 MLN-treated K562 cells,
- GSM8483000 MLN-treated K562 cells, rep2 MLN-treated K562 cells,
- GSM8483002 MLN-treated K562 cells, rep3 MLN-treated K562 cells,
- GSM8483004 IMA-treated K562 cells, rep1 IMA-treated K562 cells,
- GSM8483005 IMA-treated K562 cells, rep2 IMA-treated K562 cells,
- GSM8483006 IMA-treated K562 cells, rep3 IMA-treated K562 cells,
- GSM8483007 MLN+IMA-treated K562 cells, rep1 MLN+IMA-treated K562 ce…
- GSM8483008 MLN+IMA-treated K562 cells, rep2 MLN+IMA-treated K562 ce…
- GSM8483009 MLN+IMA-treated K562 cells, rep3 MLN+IMA-treated K562 ce…
- GSE28303 An East-Asian polymorphism underlies BCR-ABL mutation-independent resistance to tyrosine kinase inhibitors in chronic myelogenous leukemia 6 samples same disease briefing · shares inhibitors, tyrosine, leukemia
- GSE292088 Martinostat as a Novel HDAC Inhibitor to Overcome Tyrosine Kinase Inhibitor Resistance in Chronic Myeloid Leukemia 15 samples same disease briefing · shares tyrosine, leukemia
- GSE276122 Combined targeting of GPX4 and BCR-ABL tyrosine kinase selectively compromises BCR-ABL+ leukemia stem cells 4 samples same disease briefing · shares tyrosine, leukemia
- GSE267912 CDK6 kinase inhibition opens up metabolic dependencies in BCR-ABL+ leukemia 45 samples same disease briefing · shares leukemia
- GSE248894 Effect of Si-711, a dual sirtuin 1 and 2 inhibitor, on gene expression in chronic myeloid leukemia K-562 cells 12 samples same disease briefing · shares leukemia
- GSE305108 Bioinformatics differential expression analysis of the effect of cannabidiol in chronic myeloid leukemia cell line 9 samples same disease briefing · shares leukemia
- GSE198142 Selective translational control by PABPC1 phase separation regulates blast crisis and target therapy resistance of chronic myeloid leukemia 8 samples same disease briefing · shares leukemia
- GSE280476 Phosphoproteomics reveals a crucial role of FLT3 in BCR::ABL1 independent resistant chronic myeloid leukemia 7 samples same disease briefing · shares leukemia
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.