GEO series
Effect of propranolol on murine B16F10 metastasis-bearing lungs or on monocytes isolated from these lungs
GSE275763
Mus musculus
Expression profiling by high throughput sequencing
26 samples
2025/09/17
GPL24247
Summary
We demonstrate that the β-blocker propranolol strongly reduces lung metastasis in multiple murine models, with the reduction being completely dependent on CD4+ T cells. To dissect the underlying mechanisms behind the anti-metastatic effect of propranolol, an experimental B16F10 lung metastasis model was combined with propranolol treatment. Total lung RNA or RNA from FACS-isolated lung monocytes and magnetic bead-isolated CD4+ T-cells were subjected to RNA sequencing.
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Paper (PMID 41249783) ↗
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