Time courses analysis of the effect of latrunculin B-treatment on gene expression in in vitro differentiated pancreatic progenitor cells.
RNA-seq (gene expression) · human · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 16 samples: 6 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Extracellular matrix-driven metabolic control of pancreatic endocrine lineage allocationEMBO reports · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE275775_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1152967 and SRA study SRP528927. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 16 samples.
How we read this: 6 replicated groups read from 16 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8484378 D19 PPs, control, 0hr, rep1 D19 PPs, control, 0hr,
- GSM8484379 D19 PPs, control, 0hr, rep2 D19 PPs, control, 0hr,
- GSM8484380 D19 PPs, control, 0hr, rep3 D19 PPs, control, 0hr,
- GSM8484381 D19 PPs, control, 24hr, rep1 D19 PPs, control, 24hr,
- GSM8484382 D19 PPs, control, 24hr, rep2 D19 PPs, control, 24hr,
- GSM8484383 D19 PPs, LatB, 3hr, rep1 D19 PPs, LatB, 3hr,
- GSM8484384 D19 PPs, LatB, 3hr, rep2 D19 PPs, LatB, 3hr,
- GSM8484385 D19 PPs, LatB, 3hr, rep3 D19 PPs, LatB, 3hr,
- GSM8484386 D19 PPs, LatB, 6hr, rep1 D19 PPs, LatB, 6hr,
- GSM8484387 D19 PPs, LatB, 6hr, rep2 D19 PPs, LatB, 6hr,
- GSM8484388 D19 PPs, LatB, 6hr, rep3 D19 PPs, LatB, 6hr,
- GSM8484389 D19 PPs, LatB, 12hr, rep1 D19 PPs, LatB, 12hr,
- GSM8484390 D19 PPs, LatB, 12hr, rep2 D19 PPs, LatB, 12hr,
- GSM8484391 D19 PPs, LatB, 24hr, rep1 D19 PPs, LatB, 24hr,
- GSM8484392 D19 PPs, LatB, 24hr, rep2 D19 PPs, LatB, 24hr,
- GSM8484393 D19 PPs, LatB, 24hr, rep3 D19 PPs, LatB, 24hr,
- GSE272460 Transcriptome analysis of pancreatic progenitor organoids (POs) carrying PDAC related mutations, treated with ERK inhibitors and depleted of AP-1 factors 40 samples shares pancreatic, progenitor
- GSE263364 Characterization of human pancreatic tissue and organoids reveals subpopulation of intercalated duct cells with progenitor traits 23 samples shares pancreatic, progenitor
- GSE261731 Gene expression profile of in-vitro differentiated Dendritic Cells (DCs) from induced pluripotent stem cell (iPSC) and cord blood sources 19 samples shares differentiated, vitro
- GSE277202 Comprehensive Transcriptomic and Translational Profiling of Human Embryonic Stem Cell Differentiation to Definitive Endoderm and Pancreatic Progenitors via RNA-seq and Ribo-seq 14 samples shares pancreatic, progenitor
- GSE226482 Single cell RNA sequencing of spinal motor neurons and interneurons differentiated from isogenic FUS and TARDBP human induced pluripotent stem cell lines harbouring ALS-causative mutations 1415 samples shares differentiated
- GSE143584 Gene expression from laser capture microdissected epithelium and stroma during pancreatic carcinogenesis 366 samples shares pancreatic
- GSE205154 Bulk RNA-Seq gene expression data for 289 primary and metastatic pancreatic ductal adenocarcinoma (PDAC) tumor samples from FFPE blocks. 289 samples shares pancreatic
- GSE263733 Single-cell transcriptome analysis reveals subtype-specific clonal evolution and microenvironmental changes in liver metastasis of pancreatic adenocarcinoma and their clinical implications 218 samples shares pancreatic
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.