GEO series
Time courses analysis of the effect of latrunculin B-treatment on gene expression in in vitro differentiated pancreatic progenitor cells.
GSE275775
Homo sapiens
Expression profiling by high throughput sequencing
16 samples
2025/02/19
GPL21697
Summary
The organization of the actin cytoskeleton is known to influence the endocrine versus ductal fate choice during pancreas development via YAP. However, the intermediate mechanism between changes to actin polymerization and changes in YAP activity during pancreas development has not been identified. Pharmacological inhibition of actin polymerization has also been shown to be a stronger inducer of endocrine fate choice than pharmacological inhibition of YAP activity, indicating that actin depolymerization may induce endocrine fate choice via additional pathways. To identify these mechanisms, we performed bulk RNA-sequencing of in vitro differentiated ESC-derived pancreatic progenitor cells treated with latrunculin B for 3, 6, 12, or 24 hours. This sequencing dataset revealed multiple promising candidates for actin depolymerization-induced YAP inactivators and YAP-independent endocrine induction, which have been validated by additional methods.
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Paper (PMID 41145874) ↗
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