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Single cell transcriptomics of human epidermis shows decreased expression of several structural genes associated with skin barrier development in aged skin

GSE275846 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2024/08/28 Platform GPL20301
Summary
Epidermal keratinocytes are continuously dividing cells which, upon differentiation establish the outer skin barrier, the stratum corneum. In older age the epidermis becomes thinner, papillary protrusions flatten and the capacity for skin barrier repair decreases. Here we performed single-cell RNA sequencing of epidermal keratinocytes obtained by suction blisters from the volar forearm of younger (20-30) and older (65-70) healthy female individuals.
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Direct links to NCBI, no account and no request form: the whole study as GSE275846_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1153275 and SRA study SRP529072. Searching any of these in the dataset finder brings you back here.

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