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Gene expression profile of Cd45 positive cells in single cell level from KRASLSL.G12D/+P53LSL.R172H/+Pdx-Cre mice (KPC tumor mouse) model treated with stimulator of interferon genes (STING) and lymphotoxin-beta receptor (LTbR) agonist [2024_v2]

GSE275876 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2025/07/22 Platform GPL34290
Summary
The combination treatment using STING and LTbR agonists improves the immune landscape in KPC tumor model. We used single-cell RNA sequence (scRNAseq) analysis to investigate the characteristics of Cd45 positive cells after treating the tumor.
Published in
Simultaneous STING and lymphotoxin-β receptor activation induces B cell responses in tertiary lymphoid structures to potentiate antitumor immunity
Sawada J, Kikuchi Y, Duah M et al. · Nature immunology 2025 · PMID 40897896 · doi:10.1038/s41590-025-02259-8
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Also filed as BioProject PRJNA1153447 and SRA study SRP529142. Searching any of these in the dataset finder brings you back here.

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