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H4K16 acylations fine-tune transcriptional response during metabolic perturbations (ATAC-seq)

GSE275932 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 4 samples Submitted 2025/12/01 Platform GPL21103
Summary
We studied the concerted effects of the H4K16 acylations in vivo using a mouse model of the metabolic disorder propionic acidemia (PA), which causes metabolic challenges and systemic shifts in acyl-CoA ratios. Our findings indicate that H4K16 acylations act in vivo in a coordinated manner, allowing fine-tuning of transcriptional responses to metabolic stresses. Our work provides insights into the adaptive mechanisms of chromatin regulation in response to metabolic challenges.
Published in
H4K16 acylations destabilize chromatin architecture and facilitate transcriptional response during metabolic perturbations
Nitsch S, Coraor AE, Schauer T et al. · Molecular cell 2026 · PMID 41421336 · doi:10.1016/j.molcel.2025.11.030
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Also filed as BioProject PRJNA1153609 and SRA study SRP529206. Searching any of these in the dataset finder brings you back here.

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