Clonally expanded targetable natural killer-like T cells seed the aged spinal cord to disrupt wound healing [scGEX and TCR]
Single-cell RNA-seq · mouse · 24 samples
- What it is
- Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart. Read from the summary: GEO's own type field only says 'expression profiling by sequencing', so confirm it in the paper.
- Organism
- Mus musculus (mouse)
- Samples
- 24 samples: 6 conditions, mostly with about 4 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Clonally expanded, targetable, natural killer-like NKG7 T cells seed the aged spinal cord to disrupt myeloid-dependent wound healingNeuron · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE275982_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1154001 and SRA study SRP529429. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 24 samples.
How we read this: 6 replicated groups read from 24 sample titles; they account for 24 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8488938 Old-naive_GEX, replicate 1 Old-naive_GEX,
- GSM8488939 Old-naive_TCR, replicate 1 Old-naive_TCR,
- GSM8488940 Old-naive_GEX, replicate 2 Old-naive_GEX,
- GSM8488941 Old-naive_TCR, replicate 2 Old-naive_TCR,
- GSM8488942 Old-naive_GEX, replicate 3 Old-naive_GEX,
- GSM8488943 Old-naive_TCR, replicate 3 Old-naive_TCR,
- GSM8488944 Old-naive_GEX, replicate 4 Old-naive_GEX,
- GSM8488945 Old-naive_TCR, replicate 4 Old-naive_TCR,
- GSM8488946 Old-28dpi_GEX, replicate 1 Old-28dpi_GEX,
- GSM8488947 Old-28dpi_TCR, replicate 1 Old-28dpi_TCR,
- GSM8488948 Old-28dpi_GEX, replicate 2 Old-28dpi_GEX,
- GSM8488949 Old-28dpi_TCR, replicate 2 Old-28dpi_TCR,
- GSM8488950 Old-28dpi_GEX, replicate 3 Old-28dpi_GEX,
- GSM8488951 Old-28dpi_TCR, replicate 3 Old-28dpi_TCR,
- GSM8488952 Old-28dpi_GEX, replicate 4 Old-28dpi_GEX,
- GSM8488953 Old-28dpi_TCR, replicate 4 Old-28dpi_TCR,
- GSM8488954 Young-28dpi_GEX, replicate 1 Young-28dpi_GEX,
- GSM8488955 Young-28dpi_TCR, replicate 1 Young-28dpi_TCR,
- GSM8488956 Young-28dpi_GEX, replicate 2 Young-28dpi_GEX,
- GSM8488957 Young-28dpi_TCR, replicate 2 Young-28dpi_TCR,
- GSM8488958 Young-28dpi_GEX, replicate 3 Young-28dpi_GEX,
- GSM8488959 Young-28dpi_TCR, replicate 3 Young-28dpi_TCR,
- GSM8488960 Young-28dpi_GEX, replicate 4 Young-28dpi_GEX,
- GSM8488961 Young-28dpi_TCR, replicate 4 Young-28dpi_TCR,
- GSE281205 Clonally expanded targetable natural killer-like T cells seed the aged spinal cord to disrupt wound healing [scRNA-seq] 18 samples shares killer-like, targetable, clonally, expanded, natural, disrupt, healing
- GSE285414 Functional memory T cells are derived from exhausted clones and expanded by checkpoint blockade [scRNATCR_rechallenge] 21 samples shares tcr, expanded
- GSE285411 Functional memory T cells are derived from exhausted clones and expanded by checkpoint blockade [scRNATCR_Atlas] 21 samples shares tcr, expanded
- GSE285412 Functional memory T cells are derived from exhausted clones and expanded by checkpoint blockade [scRNATCR_aPDL1] 9 samples shares tcr, expanded
- GSE336063 Single-Cell RNA sequencing reveals clonally-expanded CD4+ tissue-resident memory T cells in Histidyl-tRNA Synthetase-induced myositis [RNA-seq] 16 samples shares clonally, expanded
- GSE287555 Stage-specific roles of clonally expanded CD8+ T cells in regulating amyloid pathology in Alzheimer's disease models 5 samples shares clonally, expanded
- GSE304763 A pan-immunotherapy signature to predict intratumoral CD8+ T cell expansions [scTCR_immunotherapies] 91 samples shares tcr
- GSE304629 A pan-immunotherapy signature to predict intratumoral CD8+ T cell expansions [scTCR_untreated] 52 samples shares tcr
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.