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Transcriptome regulated by mitochondrial uncouplers in prostate cancer cells

GSE276044 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/11/18 Platform GPL16791
Summary
We discovered that mitochondrial uncouplers represented by nitazoxanide and its active metabolite tizoxanide inhibited prostate cancer growth. This RNA-seq study aims to elucidate the mechanism by which mitochondrial uncouplers inhibit prostate cancer growth. The results indicate that mitochondrial uncouplers predominantly downregulated E2F1 target genes and thus likely inhibited prostate cancer growth through impeding E2F1-mediated transcription.
Published in
Mitochondrial uncouplers inhibit oncogenic E2F1 activity and prostate cancer growth
Hawsawi O, Xue W, Du T et al. · Cell reports. Medicine 2025 · PMID 39793570 · doi:10.1016/j.xcrm.2024.101890
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Also filed as BioProject PRJNA1154570 and SRA study SRP529600. Searching any of these in the dataset finder brings you back here.

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