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Targeting CD93 on Monocytes revitalizes Anti-Tumor Immunity by Enhancing the Function and Infiltration of CD8+ T Cells

GSE276062 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2024/10/30 Platform GPL29480
Summary
In this study, we found that monocytes in the peritumoral tissues of HCC significantly increased levels of CD93 expression, and these CD93+ monocytes collocated with CD8+ T cells, whose density was much higher in peri-tumor than intra-tumor areas. In vitro experiments showed that glycolytic switch mediated tumor-induced CD93 up-regulation in monocytes via the Erk signaling pathway. CD93 on the one hand could enhance PD-L1 expression through the AKT-GSK3β axis, while on the other hand induce monocytes to produce versican, a type of matrix component which interacted with hyaluronan and collagens to inhibit CD8+ T cell migration. Consistently, levels of CD93+ monocytes positively correlated with the density of peritumoral CD8+ T cells while negatively correlated with that of intratumoral CD8+ T cells. Targeting CD93 on monocytes not only increased the infiltration and activation of CD8+ T cells, but also enhanced tumor sensitivity to anti-PD-1 treatment in mice in vivo.
Published in
Targeting CD93 on monocytes revitalizes antitumor immunity by enhancing the function and infiltration of CD8(+) T cells
Jiang D, Huang A, Zhu BX et al. · Journal for immunotherapy of cancer 2024 · PMID 39448202 · doi:10.1136/jitc-2024-010148
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Also filed as BioProject PRJNA1154620 and SRA study SRP529682. Searching any of these in the dataset finder brings you back here.

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